SUBSTRATE AND MECHANOTRANSDUCTION INFLUENCE SERCA2A LOCALIZATION IN HUMAN PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES AFFECTING FUNCTIONAL PERFORMANCE

Substrate and mechanotransduction influence SERCA2a localization in human pluripotent stem cell-derived cardiomyocytes affecting functional performance

Physical cues are major determinants of cellular phenotype and evoke physiological and pathological responses on cell structure and function.Cellular models aim to recapitulate basic functional features of their in vivo counterparts or tissues in order to be of use in in vitro disease modeling or drug screening and testing.Understanding how culture

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Do consanguineous parents of a child affected by an autosomal recessive disease have more DNA identical-by-descent than similarly-related parents with healthy offspring? Design of a case-control study

Abstract Background The offspring of consanguineous relations have an increased risk of congenital/genetic disorders and early mortality.Consanguineous couples and their offspring account for approximately 10% of the global population.The increased risk for congenital/genetic disorders is most marked for autosomal recessive disorders and depends on

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